Recent in vivo evidences of particle-based delivery of small-interfering RNA (siRNA) into solid tumors

Y Wen, WS Meng - Journal of pharmaceutical innovation, 2014 - Springer
Small-interfering RNA (siRNA) is both a powerful tool in research and a promising
therapeutic platform to modulate expression of disease-related genes. Malignant tumors are …

Liposomal siRNA nanocarriers for cancer therapy

B Ozpolat, AK Sood, G Lopez-Berestein - Advanced drug delivery reviews, 2014 - Elsevier
Small interfering RNAs (siRNA) have recently emerged as a new class of therapeutics with a
great potential to revolutionize the treatment of cancer and other diseases. A specifically …

Small delivery vehicles of siRNA for enhanced cancer targeting

HJ Kim, Y Yi, A Kim, K Miyata - Biomacromolecules, 2018 - ACS Publications
Small interfering RNA (siRNA) drugs have been considered to treat various diseases in
major organs. However, siRNA drugs developed for cancer therapy are hindered from …

Delivery of small interfering RNAs by nanovesicles for cancer therapy

S Pengnam, S Plianwong, B Yingyongnarongkul… - Drug Metabolism and …, 2022 - Elsevier
Small interfering ribonucleic acids (siRNAs) are originally recognized as an intermediate of
the RNA interference (RNAi) pathway. They can inhibit or silence various cellular pathways …

Recent progress in development of siRNA delivery vehicles for cancer therapy

HJ Kim, A Kim, K Miyata, K Kataoka - Advanced drug delivery reviews, 2016 - Elsevier
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …

Nanomedicine based approaches for the delivery of siRNA in cancer

B Ozpolat, AK Sood… - Journal of internal …, 2010 - Wiley Online Library
Small interfering RNA (siRNA) technology holds great promise as a therapeutic intervention
for targeted gene silencing in cancer and other diseases. However, in vivo systemic delivery …

[HTML][HTML] Nanoparticles as drug delivery systems in cancer medicine: emphasis on RNAi-containing nanoliposomes

MR Díaz, PE Vivas-Mejia - Pharmaceuticals, 2013 - mdpi.com
Nanomedicine is a growing research field dealing with the creation and manipulation of
materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases …

[HTML][HTML] Nanoparticles-based strategies to improve the delivery of therapeutic small interfering RNA in precision oncology

J Huang, K Xiao - Pharmaceutics, 2022 - mdpi.com
Small interfering RNA (siRNA) can selectively suppress the expression of disease-causing
genes, holding great promise in the treatment of human diseases, including malignant …

Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

E Miele, GP Spinelli, E Miele, E Di Fabrizio… - International journal …, 2012 - Taylor & Francis
During recent decades there have been remarkable advances and profound changes in
cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal …

Tumor‐targeting multifunctional nanoparticles for siRNA delivery: Recent advances in cancer therapy

SH Ku, K Kim, K Choi, SH Kim… - Advanced healthcare …, 2014 - Wiley Online Library
RNA interference (RNAi) is a naturally occurring regulatory process that controls
posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi …