Rationale. The developmental history and application of the 5-choice serial reaction time
task (5CSRTT) for measuring effects of drugs and other manipulations on attentional …

BACKGROUND: Attentional deficits accompany many psychiatric disorders, underscoring
the need for rodent models of attention to screen novel therapeutic agents and characterize …

One popular way of measuring visual attentional processes in the rat is using 5-choice serial
reaction time task (5-CSRTT). This paradigm requires subjects to detect brief flashes of light …

Rationale: Beneficial effects of nicotine on cognitive processes including attention have
potential therapeutic uses and have been proposed as incentives for tobacco smoking …

Rationale. Converging evidence suggests that dopaminergic and serotonergic mechanisms
affect distinct aspects of cognitive performance. Experiments using the rodent five-choice …

Nicotine can improve attentional performance in the rat as assessed by a modified five-
choice serial reaction time task (5-CSRTT), but it is not known if the effect is shared with …

Deficits in attention and response inhibition are apparent across several neurodegenerative
and neuropsychiatric disorders for which current pharmacotherapy is inadequate. While it is …

Rationale. In studies assessing sustained attention in humans, performance is often
characterised by a decline in function over time. This response pattern, termed the vigilance …

Rationale: Whilst several studies have investigated the role of serotonergic receptor
subtypes in learning and memory, relatively few studies have examined their role in …

The present experiments investigated the effects of agents acting at serotonin (5-HT)-2
receptors on the performance of rats in a choice serial reaction time (5-CSRT) task in order …