Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …

The present study investigates the analgesic effect of minocycline, a semi-synthetic
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …

Microglia, the intrinsic macrophages of the central nervous system, have previously been
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …

Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …