Minocycline, a tetracycline with anti-inflammatory properties, has been reported to down-
regulate the activity of microglia, whose activation occurs in inflammatory and degenerative …

Initial studies conducted on the neuroprotective effects of minocycline, a second-generation
tetracycline, in experimental models of neurodegeneration gave promising results. However …

Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …

Background Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin,
have anti-inflammatory activities and are both used in the management of rheumatoid …

Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …

Rationale The role of glial cells, especially microglia and astrocytes, in neuroinflammation
and cognition has been studied intensively. Lipopolysaccharide (LPS), a commonly used …

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of the electron transport enzyme
succinate dehydrogenase, a mitochondrial Complex II enzyme. Minocycline is a semi …

Metabotropic glutamate (mGlu) receptors, which are present on neurons and glial cells,
have been shown to play a role in neuropathic pain. The present study sought to investigate …

Background Diabetic neuropathic pain (DNP) is a common and distressing complication in
patients with diabetes, and the underlying mechanism remains unclear. Tricyclic …

Minocycline is commonly used to inhibit microglial activation. It is widely accepted that
activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory …