With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …

Fueled by the explosion of (meta) genomic data, genome mining of specialized metabolites
has become a major technology for drug discovery and studying microbiome ecology. In …

In the discovery of secondary metabolites, analysis of sequence data is a promising
exploration path that remains largely underutilized due to the lack of computational platforms …

Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural
product discovery by enabling the rapid investigation of secondary metabolic potential within …

Microbial secondary metabolism is a reservoir of bioactive compounds of immense
biotechnological and biomedical potential. The biosynthetic machinery responsible for the …

Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …

Plant specialized metabolites are chemically highly diverse, play key roles in host–microbe
interactions, have important nutritional value in crops and are frequently applied as …

Background Genome mining for biosynthetic gene clusters (BGCs) has become an integral
part of natural product discovery. The> 200,000 microbial genomes now publicly available …

Secondary metabolites produced by microbes have diverse biological functions, which
makes them a great potential source of biotechnologically relevant compounds with …

Background Co-localized sets of genes that encode specialized functions are common
across microbial genomes and occur in genomes of larger eukaryotes as well. Important …