The cytokine IL6 has a number of tumor-promoting activities in human and experimental
cancers, but its potential as an angiogenic agent has not been fully investigated. Here, we …

Angiogenesis, a key rate-limiting step in the growth and dissemination of malignant tumors,
is regulated by the balance between positive and negative effectors. Recent studies indicate …

Abstract Angiopoietin (Ang)-1 is an important regulator of endothelial cell (EC) survival and
stabilization. Ang-1 exerts its biological effects by binding to the EC-specific tyrosine kinase …

Tumor angiogenesis is one of the hallmarks of tumor progression and is essential for
invasiveness and metastasis. Myeloid inflammatory cells, such as immature myeloid …

Interleukin‐8 (IL‐8) is associated with tumorigenesis by promoting angiogenesis and
metastasis. Although up‐regulation of IL‐8 is indicated in many cancers, its function in …

ABSTRACT Interleukin‐18 (IL‐18), also called interferon‐γ (IFN‐γ)‐inducing factor, has
recently been characterized as a potent IFN‐γ‐inducing cytokine. We now report that IL‐18 …

Abstract Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by T
lymphocytes and drawing attention as an inhibitor of tumor angiogenesis. In this study, we …

During the past decade, incorporating anti-angiogenic agents into the therapeutic
management of a myriad of malignancies has in certain cases made a significant impact on …

Angiogenesis, or generation of new blood vessels from pre-existing vessels, is an integral
part of many physiological or pathological processes, including tumor growth. Physiological …

Abstract Interleukin‐8 (IL‐8), a chemokine with a defining CXC amino acid motif, is known to
possess tumorigenic and proangiogenic properties. Overexpression of IL‐8 has been …