Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation
The cholinergic anti-inflammatory reflex (CAIR) represents an important homeostatic
regulatory mechanism for sensing and controlling the body's response to inflammatory …
regulatory mechanism for sensing and controlling the body's response to inflammatory …
An α7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes
MB Marrero, R Lucas, C Salet, TA Hauser… - … of Pharmacology and …, 2010 - ASPET
Type 2 diabetes has become a pervasive public health problem. The etiology of the disease
has not been fully defined but appears to involve abnormalities in peripheral and central …
has not been fully defined but appears to involve abnormalities in peripheral and central …
α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells
Enteroendocrine L cells secrete the incretin hormone glucagon-like peptide-1 (GLP-1), and
they also express the α 7 nicotinic acetylcholine receptor (α 7nAChR), which may regulate …
they also express the α 7 nicotinic acetylcholine receptor (α 7nAChR), which may regulate …
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats
AM DiBrog, KA Kern, A Mukherjee, JT Przybysz… - Pharmacology …, 2022 - Elsevier
Obesity is a prevalent disease, but effective treatments remain limited. Agonists of the alpha-
7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in mice, but …
7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in mice, but …
The nicotinic acetylcholine receptor α7 in subcutaneous mature adipocytes: downregulation in human obesity and modulation by diet-induced weight loss
R Cancello, A Zulian, S Maestrini… - International journal of …, 2012 - nature.com
BACKGROUND: It is known that cholinergic anti-inflammatory reflex regulates inflammation
in peripheral tissues. Nicotinic acetylcholine receptors (nAChRs) are mediators of this anti …
in peripheral tissues. Nicotinic acetylcholine receptors (nAChRs) are mediators of this anti …
[HTML][HTML] The role of alpha-7 nicotinic receptors in food intake behaviors
KL McFadden, MA Cornier, JR Tregellas - Frontiers in psychology, 2014 - frontiersin.org
Nicotine alters appetite and energy expenditure, leading to changes in body weight. While
the exact mechanisms underlying these effects are not fully established, both central and …
the exact mechanisms underlying these effects are not fully established, both central and …
ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity
G Scabia, R Cancello, C Dallanoce, S Berger… - Journal of …, 2020 - Springer
Purpose The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation
of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of …
of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of …
Activation of α7nAChR via vagus nerve prevents obesity-induced insulin resistance via suppressing endoplasmic reticulum stress-induced inflammation in Kupffer …
J Deng, M Wang, Y Guo, H Fischer, X Yu, D Kem… - Medical hypotheses, 2020 - Elsevier
Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the
state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism …
state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism …
[PDF][PDF] JAK2/STAT3 pathway is required for α7nAChR-dependent expression of POMC and AGRP neuropeptides in male mice
CM Souza, CL do Amaral, SC Souza… - Cell Physiol …, 2019 - pdfs.semanticscholar.org
Abstract Background/Aims: Cholinergic signalling mediated by the activation of muscarinic
and nicotinic receptors has been described in the literature as a classic and important …
and nicotinic receptors has been described in the literature as a classic and important …
The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db …
Q Meng, OG Chepurny, CA Leech… - Diabetes, Obesity …, 2022 - Wiley Online Library
Aim To establish if alpha‐7 nicotinic acetylcholine receptor (α7nAChR) agonist GTS‐21
exerts a blood glucose‐lowering action in db/db mice, and to test if this action requires …
exerts a blood glucose‐lowering action in db/db mice, and to test if this action requires …