The cholinergic anti-inflammatory reflex (CAIR) represents an important homeostatic
regulatory mechanism for sensing and controlling the body's response to inflammatory …

Type 2 diabetes has become a pervasive public health problem. The etiology of the disease
has not been fully defined but appears to involve abnormalities in peripheral and central …

Enteroendocrine L cells secrete the incretin hormone glucagon-like peptide-1 (GLP-1), and
they also express the α 7 nicotinic acetylcholine receptor (α 7nAChR), which may regulate …

Obesity is a prevalent disease, but effective treatments remain limited. Agonists of the alpha-
7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in mice, but …

BACKGROUND: It is known that cholinergic anti-inflammatory reflex regulates inflammation
in peripheral tissues. Nicotinic acetylcholine receptors (nAChRs) are mediators of this anti …

Nicotine alters appetite and energy expenditure, leading to changes in body weight. While
the exact mechanisms underlying these effects are not fully established, both central and …

Purpose The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation
of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of …

Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the
state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism …

Abstract Background/Aims: Cholinergic signalling mediated by the activation of muscarinic
and nicotinic receptors has been described in the literature as a classic and important …

Aim To establish if alpha‐7 nicotinic acetylcholine receptor (α7nAChR) agonist GTS‐21
exerts a blood glucose‐lowering action in db/db mice, and to test if this action requires …