Additive method for the prediction of protein− peptide binding affinity. Application to the MHC class I molecule HLA-A* 0201

IA Doytchinova, MJ Blythe… - Journal of proteome …, 2002 - ACS Publications
A method has been developed for prediction of binding affinities between proteins and
peptides. We exemplify the method through its application to binding predictions of peptides …

Toward the quantitative prediction of T-cell epitopes: QSAR studies on peptides having affinity with the class I MHC molecular HLA-A* 0201

L Zhihua, W Yuzhang, Z Bo, N Bing… - Journal of Computational …, 2004 - liebertpub.com
It would be useful for vaccine development to develop a method of rapidly identifying
peptide epitopes. In this paper, the empirical three-dimensional quantitative structure-affinity …

Physicochemical explanation of peptide binding to HLA‐A* 0201 major histocompatibility complex: a three‐dimensional quantitative structure‐activity relationship …

IA Doytchinova, DR Flower - Proteins: Structure, Function, and …, 2002 - Wiley Online Library
A three‐dimensional quantitative structure‐activity relationship method for the prediction of
peptide binding affinities to the MHC class I molecule HLA‐A* 0201 was developed by …

Toward prediction of binding affinities between the MHC protein and its peptide ligands using quantitative structure-affinity relationship approach

F Tian, F Lv, P Zhou, Q Yang… - Protein and Peptide …, 2008 - ingentaconnect.com
It is important but challenging to determine the binding specificity of MHC-peptide
interactions accurately and to predict their binding affinity quantitatively. In this paper, we …

Predicting binding affinities of protein ligands from three-dimensional models: application to peptide binding to class I major histocompatibility proteins

D Rognan, SL Lauemøller, A Holm… - Journal of medicinal …, 1999 - ACS Publications
A simple and fast free energy scoring function (Fresno) has been developed to predict the
binding free energy of peptides to class I major histocompatibility (MHC) proteins. It differs …

Examining the independent binding assumption for binding of peptide epitopes to MHC-I molecules

B Peters, W Tong, J Sidney, A Sette, Z Weng - Bioinformatics, 2003 - academic.oup.com
Motivation: Various methods have been proposed to predict the binding affinities of peptides
to Major Histocompatibility Complex class I (MHC-I) molecules based on experimental …

Predicting affinity and specificity of antigenic peptide binding to major histocompatibility class I molecules

F Sieker, A May, M Zacharias - Current Protein and Peptide …, 2009 - ingentaconnect.com
Major Histo-Compatibility (MHC) class I molecules are major agents of the mammalian
adaptive immune system. Class I molecules bind short antigenic peptides with a length of 8 …

Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network.

V Brusic, G Rudy, G Honeyman… - Bioinformatics …, 1998 - academic.oup.com
MOTIVATION: Prediction methods for identifying binding peptides could minimize the
number of peptides required to be synthesized and assayed, and thereby facilitate the …

In silico quantitative prediction of peptides binding affinity to human MHC molecule: an intuitive quantitative structure–activity relationship approach

F Tian, L Yang, F Lv, Q Yang, P Zhou - Amino Acids, 2009 - Springer
In this paper, we have handpicked 23 kinds of electronic properties, 37 kinds of steric
properties, 54 kinds of hydrophobic properties and 5 kinds of hydrogen bond properties from …

Derivation of an amino acid similarity matrix for peptide: MHC binding and its application as a Bayesian prior

Y Kim, J Sidney, C Pinilla, A Sette, B Peters - BMC bioinformatics, 2009 - Springer
Background Experts in peptide: MHC binding studies are often able to estimate the impact of
a single residue substitution based on a heuristic understanding of amino acid similarity in …