Early brain injury after poor-grade subarachnoid hemorrhage

V Rass, R Helbok - Current neurology and neuroscience reports, 2019 - Springer
Abstract Purpose of Review Over the last years, the focus of clinical and animal research in
subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based …

Early brain injury after subarachnoid hemorrhage: incidence and mechanisms

DC Lauzier, K Jayaraman, JY Yuan, D Diwan… - Stroke, 2023 - Am Heart Assoc
Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant
morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in …

Rethinking the initial changes in subarachnoid haemorrhage: focusing on real-time metabolism during early brain injury

Y Chen, I Galea, RL Macdonald, GKC Wong… - …, 2022 - thelancet.com
Over the last two decades, neurological researchers have uncovered many
pathophysiological mechanisms associated with subarachnoid haemorrhage (SAH), with …

Early brain injury, an evolving frontier in subarachnoid hemorrhage research

M Fujii, J Yan, WB Rolland, Y Soejima, B Caner… - Translational stroke …, 2013 - Springer
Subarachnoid hemorrhage (SAH), predominantly caused by a ruptured aneurysm, is a
devastating neurological disease that has a morbidity and mortality rate higher than 50 …

Subarachnoid hemorrhage: is it time for a new direction?

J Cahill, JH Zhang - Stroke, 2009 - Am Heart Assoc
Background and Purpose—Despite recent advances in the treatment of patients after
subarachnoid hemorrhage, morbidity and mortality rates have failed to improve significantly …

Emerging markers of early brain injury and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage

F Al-Mufti, K Amuluru, B Smith, N Damodara… - World Neurosurgery, 2017 - Elsevier
Background Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage is
characterized by a highly complex pathophysiology and results in neurologic deterioration …

The role of platelet activation and inflammation in early brain injury following subarachnoid hemorrhage

JA Frontera, JJ Provencio, FA Sehba, TM McIntyre… - Neurocritical care, 2017 - Springer
Background Early brain injury (EBI) following aneurysmal subarachnoid hemorrhage (SAH)
is an important predictor of poor functional outcome, yet the underlying mechanism is not …

Mechanisms of early brain injury after subarachnoid hemorrhage

WJ Cahill, JH Calvert, JH Zhang - Journal of Cerebral Blood …, 2006 - journals.sagepub.com
Apoptosis is the term given to programmed cell death, which has been widely connected to
a number of intracranial pathologies including stroke, Alzheimer's disease, and more …

The subarachnoid hemorrhage early brain edema score predicts delayed cerebral ischemia and clinical outcomes

SH Ahn, JP Savarraj, M Pervez, W Jones, J Park… - …, 2018 - journals.lww.com
BACKGROUND Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an
important determinant of clinical outcomes. However, a major hindrance to studies of EBI is …

Acute ischaemia after subarachnoid haemorrhage, relationship with early brain injury and impact on outcome: a prospective quantitative MRI study

JA Frontera, W Ahmed, V Zach, M Jovine… - Journal of Neurology …, 2015 - jnnp.bmj.com
Objective To determine if ischaemia is a mechanism of early brain injury at the time of
aneurysm rupture in subarachnoid haemorrhage (SAH) and if early MRI ischaemia …