Sodium Malonate Inhibits the AcrAB-TolC Multidrug Efflux Pump of Escherichia coli and Increases Antibiotic Efficacy
A Cauilan, C Ruiz - Pathogens, 2022 - mdpi.com
There is an urgent need to find novel treatments for combating multidrug-resistant bacteria.
Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this …
Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this …
[HTML][HTML] Suppl 1: Pimozide inhibits the AcrAB-TolC efflux pump in Escherichia coli
JA Bohnert, S Schuster, WV Kern - The open microbiology journal, 2013 - ncbi.nlm.nih.gov
Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …
Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli
TJ Opperman, SM Kwasny, HS Kim… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Members of the resistance-nodulation-division (RND) family of efflux pumps, such as AcrAB-
TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative …
TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative …
Drug efflux pump inhibitors: a promising approach to counter multidrug resistance in Gram-negative pathogens by targeting AcrB protein from AcrAB-TolC multidrug …
R Alenazy - Biology, 2022 - mdpi.com
Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …
negative bacteria, have posed serious health issues worldwide. Bacteria have different …
Novel piperazine arylideneimidazolones inhibit the AcrAB-TolC pump in Escherichia coli and simultaneously act as fluorescent membrane probes in a combined real …
In this study, we tested five compounds belonging to a novel series of piperazine
arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump. The …
arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump. The …
Efflux pumps as interventions to control infection caused by drug-resistance bacteria
Bacterial multidrug resistance (MDR) has become a major public health threat. Along with
enzymatic modifications, overexpression of MDR efflux pumps is a significant antibiotic …
enzymatic modifications, overexpression of MDR efflux pumps is a significant antibiotic …
Efflux pump inhibitors: a novel approach to combat efflux-mediated drug resistance in bacteria
Y Wang, H Venter, S Ma - Current drug targets, 2016 - ingentaconnect.com
The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …
Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates
D Ghisalberti, A Mahamoud, J Chevalier… - International journal of …, 2006 - Elsevier
Efflux mechanisms protect bacterial cells by pumping out toxic compounds and actively
contribute to bacterial multidrug resistance. Agents inhibiting efflux pumps are of interest for …
contribute to bacterial multidrug resistance. Agents inhibiting efflux pumps are of interest for …
[HTML][HTML] Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump
N Compagne, JC Jiménez-Castellanos… - European Journal of …, 2023 - Elsevier
Multidrug–resistant Escherichia coli is a continuously growing worldwide public health
problem, in which the well-known AcrAB-TolC tripartite RND efflux pump is a critical driver …
problem, in which the well-known AcrAB-TolC tripartite RND efflux pump is a critical driver …
Identification and Structure–Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli
KM Haynes, N Abdali, V Jhawar… - Journal of medicinal …, 2017 - ACS Publications
In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations
from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux …
from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux …