There is an urgent need to find novel treatments for combating multidrug-resistant bacteria.
Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this …

Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …

Members of the resistance-nodulation-division (RND) family of efflux pumps, such as AcrAB-
TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative …

Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …

In this study, we tested five compounds belonging to a novel series of piperazine
arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump. The …

Bacterial multidrug resistance (MDR) has become a major public health threat. Along with
enzymatic modifications, overexpression of MDR efflux pumps is a significant antibiotic …

The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …

Efflux mechanisms protect bacterial cells by pumping out toxic compounds and actively
contribute to bacterial multidrug resistance. Agents inhibiting efflux pumps are of interest for …

Multidrug–resistant Escherichia coli is a continuously growing worldwide public health
problem, in which the well-known AcrAB-TolC tripartite RND efflux pump is a critical driver …

In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations
from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux …