Recruited adipose tissue macrophages contribute to chronic and low-grade inflammation
causing insulin resistance in obesity. Similarly, we hypothesized here that Kupffer cells, the …

While adipose tissue-associated macrophages contribute to development of chronic
inflammation and insulin resistance of obesity, little is known about the role of hepatic …

OBJECTIVE Increased activity of the innate immune system has been implicated in the
pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 …

We aimed to evaluate activation of macrophages in insulin‐sensitive tissues (liver, adipose
tissue, and muscles) under high‐fat diet (HFD) and elucidate the role of Kupffer cells (KC) in …

Kupffer cells have been implicated in the pathogenesis of various liver diseases. However,
their involvement in metabolic disorders of the liver, including fatty liver disease, remains …

Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …

Obesity promotes insulin resistance associated with liver inflammation, elevated glucose
production, and type 2 diabetes. Although insulin resistance is attenuated in genetic mouse …

OBJECTIVE Proinflammatory activation of Kupffer cells is implicated in the effect of high-fat
feeding to cause liver insulin resistance. We sought to determine whether reduced …

Chronic inflammation is now recognized as a key step in the pathogenesis of obesity-
induced insulin resistance and type 2 diabetes mellitus. This low-grade inflammation is …

Chronic low grade inflammation in adipose tissue during obesity is associated with an
impairment of the insulin signaling cascade. In this study, we have evaluated the impact of …