Objective: 1) Determine frequency and magnitude of delays in second antibiotic
administration among patients admitted with sepsis; 2) Identify risk factors for these delays; …

Background Early antibiotics are fundamental to sepsis management. Second-dose
antibiotic delays were associated with increased mortality in a recent study. Study objectives …

OBJECTIVES: Rapid delivery of antibiotics is a cornerstone of sepsis therapy, although time
targets for specific components of antibiotic delivery are unknown. We quantified time …

Objectives: We sought to systematically review and meta-analyze the available data on the
association between timing of antibiotic administration and mortality in severe sepsis and …

Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …

Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.
Objectives: To evaluate the association between antibiotic timing and mortality among …

Objectives: Timeliness of antibiotic administration is recognized as an important factor in
reducing mortality associated with sepsis. According to guidelines, antibiotics should be …

Background We evaluated the effect of time spent in the emergency department (ED) and
process of care on mortality and length of hospital stay in patients with sepsis or septic …

Objective We aimed to investigate the effect of timely antibiotic administration on outcomes
in patients with severe sepsis and septic shock. Methods We analyzed data from a sepsis …

Background Current evidence suggests that administration of appropriate antibiotic therapy
within 1 h after the onset of hypotension significantly improves mortality rates among …