Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

Purpose The goal of this review was to synthesize existing evidence regarding outcomes
(mortality) for patients who present to the emergency department, are administered …

Sepsis constitutes an important cause of hospital admission with a high mortality rate.
Appropriate antibiotic therapy is the cornerstone of therapy in patients with sepsis. Although …

Abstract Background The Surviving Sepsis Campaign recommends initiating broad-
spectrum antibiotic treatment within 1 hour of septic shock recognition. However, there is …

Abstract The Surviving Sepsis Campaign recommends immediate antibiotics for all patients
with suspected sepsis and septic shock, ideally within 1 hour of recognition. Immediate …

OBJECTIVES: Delay of antimicrobial administration in adult patients with severe sepsis and
septic shock has been associated with a decrease in survival to hospital discharge. The …

Background Sepsis, defined as a dysregulated host response to infection leading to acute
organ dysfunction, affects millions of patients per year. It is associated with 850,000 visits to …

Background Rapid initiation of antibiotic treatment is considered crucial in patients with
severe infections such as septic shock and bacterial meningitis, but may not be as important …

Background Delays in antibiotic administration after severe sepsis recognition increases
mortality. While physician and pharmacy-related barriers to early antibiotic initiation have …

BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged
infusion of these agents is commonly performed to optimize the time the unbound …