Immune system modulation in aging: Molecular mechanisms and therapeutic targets
B Cisneros, I García-Aguirre, J Unzueta… - Frontiers in …, 2022 - frontiersin.org
The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …
Aging and immune function: molecular mechanisms to interventions
S Ponnappan, U Ponnappan - 2011 - liebertpub.com
The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …
Immunosenescence: molecular mechanisms and diseases
Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
Paradoxical changes in innate immunity in aging: recent progress and new directions
RR Montgomery, AC Shaw - Journal of Leucocyte Biology, 2015 - academic.oup.com
Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …
Intracellular signalling pathways: targets to reverse immunosenescence
T Fulop, JM Witkowski, A Le Page… - Clinical & …, 2017 - academic.oup.com
Ageing is a very complex process, the result of the dysregulation of multiple systems
interacting in many ways. A prominent change occurring with ageing is related to the …
interacting in many ways. A prominent change occurring with ageing is related to the …
How inflammation blunts innate immunity in aging
The collective loss of immune protection during aging leads to poor vaccine responses and
an increased severity of infection for the elderly. Here, we review our current understanding …
an increased severity of infection for the elderly. Here, we review our current understanding …
Immune senescence, immunosenescence and aging
With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …
which contributes to impaired immune responses to pathogens and greater mortality and …
The twilight of the immune system: The impact of immunosenescence in aging
Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …
Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
C Hieber, S Grabbe, M Bros - Biomolecules, 2023 - mdpi.com
Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …
The increased production of pro-inflammatory cytokines by innate immune cells under basal …
Aging of the immune system: research challenges to enhance the health span of older adults
L Haynes - Frontiers in aging, 2020 - frontiersin.org
The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …
biological process of aging is by far the greatest risk factor for most chronic diseases …