Abstract The Mitochondrial Permeability Transition (MPT) pore is a voltage-sensitive
unselective channel known to instigate necrotic cell death during cardiac disease. Recent …

The mitochondrial permeability transition pore (MPTP) is a non-specific pore that opens in
the inner mitochondrial membrane (IMM) when matrix [Ca 2+] is high, especially when …

Under conditions of mitochondrial calcium overload, especially when accompanied by
oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a …

Aims Knockout (KO) of the mitochondrial Ca2+ uniporter (MCU) in mice abrogates
mitochondrial Ca2+ uptake and permeability transition pore (PTP) opening. However, hearts …

The mitochondrial permeability transition pore (MPTP) plays a key role in cell death, yet its
molecular identity remains uncertain. Although knock-out studies have confirmed critical …

The mitochondrial permeability transition pore (mPTP) is a channel in the inner
mitochondrial membrane whose sustained opening in response to elevated mitochondrial …

Most of the experimental studies have revealed that female heart is more tolerant to
ischemia/reperfusion (I/R) injury as compared with the male myocardium. It is widely …

Despite the lack of its molecular identification, the mitochondrial permeability transition pore
(PTP) is a fascinating subject because of its important role in cell death. This holds …

Mitochondria play a central role in heart energy metabolism and Ca2+ homeostasis and are
involved in the pathogenesis of many forms of heart disease. The body of knowledge on …

The mitochondrial permeability transition pore (mPTP) plays a critical role in the
pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although …