Specific helix− helix interactions are fundamental in assembling the native state of proteins
and in protein− protein interfaces. Coiled coils afford a unique model system for elucidating …

Background The mechanism by which the signals are transmitted between receptor and
effector domains in multi-domain signaling proteins is poorly understood. Results Using …

The regulation of a series of cellular events requires specific protein–protein interactions,
which are usually mediated by modular domains to precisely select a particular sequence …

Kinase Activity: Probing conformational dynamics to understand kinase inhibition | eLife Skip to
Content eLife logo eLife home page Menu Home Magazine Community About Search Alerts …

Competing positive and negative signaling feedback pathways play a critical role in tuning
the sensitivity of T cell receptor activation by creating an ultrasensitive, bistable switch to …

Biology | Free Full-Text | Multi-Facial, Non-Peptidic α-Helix Mimetics Next Article in Journal The
Impact of Photobleaching on Microarray Analysis Previous Article in Journal The Mucosal …

Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …

Cover: This month s cover highlights the Research Article Pooled-matrix protein
interaction screens using Barcode Fusion Genetics by Nozomu Yachie, Evangelia …

Ankyrin repeat (AR) proteins are one of the most abundant repeat protein classes in nature,
and they are involved in numerous physiological processes through mediating …

Many substrates of ERK2 contain a D-site, a sequence recognized by ERK2 that is used to
promote catalysis. Despite lacking a canonical D-site, the substrate Ets-1 is displaced from …