Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1‐Foxo1 and PI3K‐Akt signalling pathways

B Ren, Y Zhang, S Liu, X Cheng, X Yang… - Journal of cellular …, 2020 - Wiley Online Library
Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic
cardiomyopathy (DCM) is one of the type 2 diabetes complications, usually accompanied by …

Curcumin and insulin resistance—molecular targets and clinical evidences

AS Jiménez‐Osorio, A Monroy, S Alavez - Biofactors, 2016 - Wiley Online Library
Abstract Curcumin ((1E, 6E)− 1, 7‐bis (4‐hydroxy‐3‐methoxyphenyl)‐1, 6‐heptadiene‐3, 5‐
dione), the main component of the Indian spice turmeric, has been used in traditional …

Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat model

M Rahnavard, M Hassanpour, M Ahmadi… - Journal of cellular …, 2019 - Wiley Online Library
Cardiovascular diseases are the main cause of death globally. Many attempts have been
done to ameliorate the pathological changes after the occurrence of myocardial infarction …

Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts

K Zikaki, IK Aggeli, C Gaitanaki, I Beis - Apoptosis, 2014 - Springer
Curcumin derived from the rhizome of turmeric (Curcuma longa L.), is a well known coloring
culinary agent, that has therapeutic properties against diverse pathologies such as cancer …

Molecular mechanisms underlying curcumin‐mediated therapeutic effects in type 2 diabetes and cancer

M Wojcik, M Krawczyk, P Wojcik… - Oxidative medicine …, 2018 - Wiley Online Library
The growing prevalence of age‐related diseases, especially type 2 diabetes mellitus
(T2DM) and cancer, has become global health and economic problems. Due to multifactorial …

Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model

S Sudirman, CS Lai, YL Yan, HI Yeh, ZL Kong - Scientific Reports, 2019 - nature.com
High blood glucose in diabetic patients often causes cardiovascular diseases (CVDs) that
threats to human life. Curcumin (Cur) is known as an antioxidant agent, possesses anti …

The clinical applications of curcumin: current state and the future

X Fan, C Zhang, D Liu, J Yan… - Current pharmaceutical …, 2013 - ingentaconnect.com
Curcumin is a natural polyphenol product derived from the rhizome of the Curcuma longa. In
vivo and in vitro studies have uncovered many important bioactivities of curcumin, such as …

[HTML][HTML] Tetrahydrocurcumin ameliorates postinfarction cardiac dysfunction and remodeling by inhibiting oxidative stress and preserving mitochondrial function via …

B Zhang, J Yang, X Li, H Zhu, J Sun, L Jiang, C Xue… - Phytomedicine, 2023 - Elsevier
Background Myocardial infarction (MI) often leads to sudden cardiac death. Persistent
myocardial ischemia increases oxidative stress and impairs mitochondrial function …

[HTML][HTML] An examination of the protective effects and molecular mechanisms of curcumin, a polyphenol curcuminoid in diabetic nephropathy

X Zhu, X Xu, C Du, Y Su, L Yin, X Tan, H Liu… - Biomedicine & …, 2022 - Elsevier
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and is an
enormous burden on both patients and society. There is an urgent need for effective …

A comprehensive review on the benefits and problems of curcumin with respect to human health

S Liu, J Liu, L He, L Liu, B Cheng, F Zhou, D Cao, Y He - Molecules, 2022 - mdpi.com
Curcumin is the most important active component in turmeric extracts. Curcumin, a natural
monomer from plants has received a considerable attention as a dietary supplement …