Osteosarcoma and Ewing's sarcoma tumor cells are susceptible to IL15-induced or antibody-
mediated cytolytic activity of NK cells in short-term cytotoxicity assays. When encountering …

Natural killer cells are critical players in the antitumor immune response due to their ability to
destroy target cells through cytotoxic activity and other means. However, this response is …

High-grade osteosarcoma occurs predominantly in adolescents and young adults and has
an overall survival rate of about 60%, despite chemotherapy and surgery. Therefore, novel …

Background The possibility that autologous NK cells could serve as an effective treatment
modality for solid tumors has long been considered. However, implementation is hampered …

We provide evidence that tumor cells can induce apoptosis of NK cells by engaging the
natural cytotoxicity receptors (NCR) NKp30, NKp44, and NKp46. Indeed, the binding …

INTRODUCTION: Ewing sarcoma (EWS) is a malignant bone-associated sarcoma, with poor
prognosis in case of metastasis or relapse. To explore the feasibility of natural killer (NK) cell …

The recent findings on NK activation indicate that these cells are important antitumor
effectors. NK cells participate in the graft-vs.-leukemia effect to control the relapse in …

Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid
tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant …

Monoclonal antibodies represent a promising approach to fight a variety of tumors, but their
mode of action remains to be fully understood. NK cells can recognize Ab-coated targets, as …

Simple Summary Sarcomas are a group of aggressive tumors originating from mesenchymal
tissues. Patients with advanced disease have poor prognosis due to the ineffectiveness of …