[图书][B] G protein-coupled receptors in drug discovery
WR Leifert - 2009 - Springer
The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a
multitude of physiological processes. The GPCRs represent one of the largest superfamilies …
multitude of physiological processes. The GPCRs represent one of the largest superfamilies …
Conducting the G-protein coupled receptor (GPCR) signaling symphony in cardiovascular diseases: new therapeutic approaches
SL Belmonte, BC Blaxall - Drug Discovery Today: Disease Models, 2012 - Elsevier
G protein-coupled receptors (GPCRs) are a virtually ubiquitous class of membrane-bound
receptors, which functionally couple hormone or neurotransmitter signals to physiological …
receptors, which functionally couple hormone or neurotransmitter signals to physiological …
Restoring function to inactivating G protein‐coupled receptor variants in the hypothalamic–pituitary–gonadal axis1
T Radomsky, RC Anderson, RP Millar… - Journal of …, 2024 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are central to the functioning of the hypothalamic–
pituitary–gonadal axis (HPG axis) and include the rhodopsin‐like GPCR family members …
pituitary–gonadal axis (HPG axis) and include the rhodopsin‐like GPCR family members …
Rescue of defective G protein–coupled receptor function in vivo by intermolecular cooperation
A Rivero-Müller, YY Chou, I Ji, S Lajic… - Proceedings of the …, 2010 - National Acad Sciences
G protein–coupled receptors (GPCRs) are ubiquitous mediators of signaling of hormones,
neurotransmitters, and sensing. The old dogma is that a one ligand/one receptor complex …
neurotransmitters, and sensing. The old dogma is that a one ligand/one receptor complex …
G-protein coupled receptor oligomerization in neuroendocrine pathways
KM Kroeger, KDG Pfleger, KA Eidne - Frontiers in Neuroendocrinology, 2003 - Elsevier
Protein–protein interactions are fundamental processes for many biological systems
including those involving the superfamily of G-protein coupled receptors (GPCRs). A …
including those involving the superfamily of G-protein coupled receptors (GPCRs). A …
Extramembranous regions in G protein-coupled receptors: Cinderella in receptor biology?
S Pal, A Chattopadhyay - The Journal of Membrane Biology, 2019 - Springer
G protein-coupled receptors (GPCRs) are the largest class of membrane proteins involved in
signal transduction and are characterized by seven transmembrane domain architecture …
signal transduction and are characterized by seven transmembrane domain architecture …
A multi-dimensional view of context-dependent G protein-coupled receptor function
M Marti-Solano - Biochemical Society Transactions, 2023 - portlandpress.com
G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of
biomolecules to activate intracellular signalling cascades that modulate key aspects of cell …
biomolecules to activate intracellular signalling cascades that modulate key aspects of cell …
Novel structural approaches to study GPCR regulation
MA Alfonzo-Méndez, R Alcántara-Hernández… - International Journal of …, 2016 - mdpi.com
Background: Upon natural agonist or pharmacological stimulation, G protein-coupled
receptors (GPCRs) are subjected to posttranslational modifications, such as phosphorylation …
receptors (GPCRs) are subjected to posttranslational modifications, such as phosphorylation …
Structural insights into emergent signaling modes of G protein–coupled receptors
I Sutkeviciute, JP Vilardaga - Journal of Biological Chemistry, 2020 - ASBMB
G protein–coupled receptors (GPCRs) represent the largest family of cell membrane
proteins, with> 800 GPCRs in humans alone, and recognize highly diverse ligands, ranging …
proteins, with> 800 GPCRs in humans alone, and recognize highly diverse ligands, ranging …
[PDF][PDF] Oligomerization of GPCRs involved in endocrine regulation
G Kleinau, A Müller, H Biebermann - J Mol Endocrinol, 2016 - researchgate.net
More than 800 different human membrane-spanning G-protein-coupled receptors (GPCRs)
serve as signal transducers at biological barriers. These receptors are activated by a wide …
serve as signal transducers at biological barriers. These receptors are activated by a wide …