Introduction: Antimicrobial resistance has become a global problem. Many pathogens are
becoming multidrug-resistant with the attendant increased risk of failure of standard …

Abstract Multidrug-resistant (MDR) Gram-negative bacteria (GNB) pose a critical threat to
global healthcare, worsening outcomes and increasing mortality among infected patients …

Background. The prevalence of multidrug resistance (MDR) among gram-negative bacilli is
rapidly increasing. Quantification of the prevalence and the common antimicrobial …

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has
increased dramatically during the last 10 years, but the optimal treatment for CRGN …

Highlights•Carbapenem-resistant Gram-negative pathogens are a priority for R&D,
according to WHO.•Increasing need for new therapies against Klebsiella, Pseudomonas and …

Background. The characteristics of colonization with multidrug-resistant gram-negative
bacteria (MDRGNB) in the gastrointestinal tract have not been well defined. Characterizing …

The emergence of multidrug-resistant (MDR) Gram-negative bacilli creates a big problem for
the treatment of nosocomial infections. As the pharmaceutical pipeline wanes, the only …

Background Increasing rates of resistant and multidrug-resistant (MDR) P. aeruginosa in
hospitalized patients constitute a major public health threat. We present a systematic review …

Management of patients with infections caused by multidrug-resistant organisms is
challenging and requires a multidisciplinary approach to achieve successful clinical …

Background Clinically relevant categorization of antimicrobial resistance is critical to
mitigating the threat it poses. Difficult-to-treat resistance (DTR) is a recently proposed …