Elucidating drug resistance in human fungal pathogens

JL Xie, EJ Polvi, T Shekhar-Guturja… - Future microbiology, 2014 - Taylor & Francis
Fungal pathogens cause life-threatening infections in immunocompetent and
immunocompromised individuals. Millions of people die each year due to fungal infections …

[图书][B] Recent trends in antifungal agents and antifungal therapy

A Basak, R Chakraborty, SM Mandal - 2016 - Springer
In the history of discoveries of fungal pathogens, the nineteenth century has witnessed two
important events. The causal organism of a silkworm disease, muscardine, a fungus named …

[图书][B] Combating fungal infections: problems and remedy

I Ahmad, M Owais, M Shahid, F Aqil - 2010 - books.google.com
Fungi are eukaryotic microorganisms that are closely related to humans at cellular level.
Human fungal pathogens belong to various classes of fungi, mainly zygo-cetes …

[HTML][HTML] Current and future antifungal therapy: new targets for antifungal therapy

VT Andriole - International journal of antimicrobial agents, 2000 - Elsevier
Invasive fungal infections will continue to cause major complications in
immunocompromized patients. At the moment, the expansion of antifungal drug research …

Emerging new targets for the treatment of resistant fungal infections

N Liu, J Tu, G Dong, Y Wang… - Journal of medicinal …, 2018 - ACS Publications
With the increasing morbidity and mortality of invasive fungal infections and the emergence
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …

Novel avenues for identification of new antifungal drugs and current challenges

J Jampilek - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction Some of the fungi have become pathogenic to humans, and these opportunistic
pathogens are able to cause severe systemic mycoses. Areas covered The number of …

Antimycotic drugs and their mechanisms of resistance to Candida species

S Dahiya, N Sharma, A Punia, P Choudhary… - Current Drug …, 2022 - ingentaconnect.com
Fungal infections have shown an upsurge in recent decades, which is mainly because of the
increasing number of immunocompromised patients and the occurrence of invasive …

Therapy for fungal diseases: opportunities and priorities

DW Denning, WW Hope - Trends in microbiology, 2010 - cell.com
This article provides a perspective on the current status of drug therapy for invasive fungal
diseases, together with priorities for the future development of novel compounds. Key …

New treatment options for critically important WHO fungal priority pathogens

L Kriegl, M Egger, J Boyer, M Hoenigl… - Clinical Microbiology and …, 2024 - Elsevier
Background Yet often overlooked in public health discourse, fungal infections pose a
crucialglobal disease burden associated with annual mortality rates approximately equal to …

Drug repurposing strategies in the development of potential antifungal agents

Q Zhang, F Liu, M Zeng, Y Mao, Z Song - Applied Microbiology and …, 2021 - Springer
The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …