Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal
carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by …

Microsatellite instability (MSI) has been described in tumors from patients with hereditary
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …

Microsatellite instability (MSI) in tumors from patients with hereditary non‐polyposis
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …

Human cancers with a high frequency microsatellite instability phenotype develop due to
defects in DNA mismatch repair genes. Silencing of a DNA mismatch repair gene, hMLH1 …

Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …

Genomic instability has been proposed as a new mechanism of carcinogenesis involved in
hereditary non-polyposis colorectal cancer (HNPCC) and in a large number of sporadic …

BACKGROUND & AIMS:: Methylation of the hMLH1 promoter region has been suggested to
cause microsatellite instability (MSI) in sporadic colorectal carcinoma (CRC). We studied the …

It has been reported that MLH1 is silenced by promoter methylation, and that this
phenomenon is associated with microsatellite instability (MSI) in sporadic colorectal cancer …

Mutations at the hMSH2 and hMLH1 mismatch repair loci have been implicated in the
pathogenesis of colorectal cancer. Tumours with two allelic mutations at a mismatch repair …