BACKGROUND Animal models are important tools to investigate the pathogenesis and
develop treatment strategies for bone metastases in humans. However, there are few …

Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

Bone metastases occur frequently in patients with advanced breast or prostate cancer. Bone
metastases can be predominantly osteolytic, osteoblastic or mixed. Studies with animal …

Currently, an in vivo model of human breast cancer metastasizing from the orthotopic site to
bone does not exist, making it difficult to study the many steps of skeletal metastasis …

PURPOSE: The metastasis of prostate cancer to bone is the most significant cause of
morbidity and mortality in this disease. An estimated 28,900 men die annually secondary to …

INVESTIGATIONS ON the pathogenesis of cancer metastasis to bone have received
increased attention by scientists worldwide. This is good news for patients that suffer from …

Bone is a common site of metastasis in human cancer. A major impediment to
understanding the pathogenesis of bone metastasis has been the lack of an appropriate …

Bone metastases are a common occurrence in several malignancies, including breast,
prostate, and lung. Once established in bone, tumors are responsible for significant …

Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …

Bone metastases are a frequent clinical problem in patients with breast, prostate, and other
cancers. Formation of these lesions is a site-specific process determined by multiple cellular …