Bone metastases are a frequent clinical problem in patients with breast, prostate, and other
cancers. Formation of these lesions is a site-specific process determined by multiple cellular …

Bone metastases cause significant morbidity and mortality in late-stage breast cancer
patients and are currently considered incurable. Investigators rely on translational models to …

BACKGROUND This review summarizes evidence that the formation of bone metastases is
the result of multiple synergistic cellular and molecular interactions between metastatic cells …

Cancer metastasis is infrequently evaluated in vivo, probably because of the few available
models and the technical challenges associated with the detection of metastases. Here we …

There is a pressing need for in vivo models in which potential antitumor agents can be
tested for their ability to inhibit the growth and metastatic spread of human sarcomas. A …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

Commonly used in vivo models of prostate cancer metastasis include syngeneic rodent
cancers and xenografts of human cancer in immuno-deficient mice. However, the …

Breast cancer metastasizes to bone with high frequency and incidence. However, studies of
breast cancer metastasis to bone have been limited by two factors. First, the number of …

This authoritative survey discusses how tumor cells cause bone metastases by producing
both local and systemic factors that disrupt the balance between bone formation and bone …

The biology of skeletal metastasis is poorly understood. In order to establish an animal
model of bone metastasis, cells from a human prostate cancer cell line (PC-3) were injected …