Advanced cancers are prone to metastasize. Visceral metastases are more likely to be fatal,
while patients with only metastases to bone can survive up to 10 years or more. However …

For metastasis to occur, tumor cells must first detach from their tissue of origin. This requires
altering both the tissue of origin and the cancer cell. Once detached, cancer cells in …

BACKGROUND To improve the therapy of advanced prostate cancer (CaP), it is critical to
develop animal models that mimic CaP bone metastases. Unlike the human disease, CaP …

Bone is the most common site of metastasis in prostate cancer (PC), and to generate an
animal model to investigate the basis of the unique organ tropism of PC cells for bone, we …

Metastasis is a complex clinical and biological problem presently under intense study, and
several model systems are in use to experimentally recapitulate and dissect the various …

The skeleton is a unique structure capable of providing support for the body. Bone
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …

Breast cancer affects approximately one woman in twelve and kills more women than any
other cancer. If detected early, patients have a five year survival rate of 66%, but once …

In patients with advanced disease, several cancer types frequently metastasize to the
skeleton, where they cause bone destruction. Osteolytic metastases are incurable and …

In human cancers, bone is a common site for metastasis. It is well known that metastasis is
the cause of morbidity and mortality in patients with cancer. Both breast and prostate …

Although radiographically skeletal metastases have been classified as sclerotic, lytic or
mixed, the basic difference in the underlying pathologic processes is minor. In the vast …