Bone is a frequent site of metastases of the most common tumors, eg, breast carcinoma and
prostate carcinoma. The functions of the skeleton, calcium homeostasis and mechanical …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

A specialized bioreactor based on the principle of simultaneous growth and dialysis permits
growth of three-dimensional (3D), multiple-cell-layer osteogenic tissue from isolated …

The development of a bone metastasis involves interactions between the tumor cells, the
bone marrow microenvironment and the bone cells themselves. A better understanding of …

LNCaP lineage‐derived human prostate cancer cell lines C4‐2 and C4‐2B4 acquire
androgen independence and osseous metastatic potential in vivo. Using C4‐2 and C4‐2B4 …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …

We used bioluminescence imaging to reveal patterns of metastasis formation by human
breast cancer cells in immunodeficient mice. Individual cells from a population established …

We developed a sensitive real-time polymerase chain reaction (QPCR) assay that allows us
to track early lodging/homing events in vivo. We used this technology to develop a …

Metastasis is a multistep and multifunctional biological cascade that is the final and most life-
threatening stage of cancer progression. Understanding the biological underpinnings of this …

Bone is one of the most preferential target sites for cancer metastasis. Breast cancer has a
predilection for spreading to bone, and bone metastasis is one of the major causes of …