Human neoplasms are biologically heterogeneous. The extensive cellular diversity found in
malignant neoplasms is generated by the rapid emergence of clonal subpopulations of …

Cell-cell and cell-matrix interactions play a major role in tumor morphogenesis and cancer
metastasis. Therefore, it is crucial to create a model with a biomimetic microenvironment that …

The variability of different primary tumors in the susceptibility to metastatic bone disease is
poorly understood. Factors that determine the viability of metastatic cells are also poorly …

Bone metastases lead to hypercalcemia, bone pain, fractures, and nerve compression. They
cause increased morbidity and mortality in patients with advanced breast cancer. Animal …

Pulmonary metastasis remains the leading ca use of death for cancer patients. Opportunities
to improve treatment outcomes for patients require new methods to study and view the …

Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to
be the most significant problem in the field of cancer. Patients who present with metastatic …

One of the major limitations of studying cancer-bone metastasis has been the lack of an
appropriate ex-vivo model which can be used under defined conditions that simulates …

Bone metastasis, or the development of secondary tumors within the bone of cancer
patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone …

The skeleton is one of the most common sites for metastatic cancer, and tumors arising from
the breast or prostate possess an increased propensity to spread to this site. The growth of …

Most patients with cancer die because the cancer metastasizes to other organs. Bone is 1 of
the 3 most common sites of tumor metastasis, and is a catastrophic complication of cancer …