Research progress on strategies that can enhance the therapeutic benefits of mesenchymal stromal cells in respiratory diseases with a specific focus on acute …

S Rolandsson Enes, AD Krasnodembskaya… - Frontiers in …, 2021 - frontiersin.org
Recent advances in cell based therapies for lung diseases and critical illnesses offer
significant promise. Despite encouraging preclinical results, the translation of efficacy to the …

[HTML][HTML] Recent insights: mesenchymal stromal/stem cell therapy for acute respiratory distress syndrome

S Horie, JG Laffey - F1000Research, 2016 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) causes respiratory failure, which is associated
with severe inflammation and lung damage and has a high mortality and for which there is …

Mesenchymal stromal cells for treatment of the acute respiratory distress syndrome: The beginning of the story

T Morrison, DF McAuley… - Journal of the …, 2015 - journals.sagepub.com
In spite of decades of research, the acute respiratory distress syndrome (ARDS) continues to
have an unacceptably high mortality and morbidity. Mesenchymal stromal cells (MSCs) …

Therapeutic potential and mechanisms of action of mesenchymal stromal cells for acute respiratory distress syndrome

GF Curley, JA Scott, JG Laffey - Current stem cell research & …, 2014 - ingentaconnect.com
Mesenchymal stem/stromal cells (MSCs) have become the focus of intense research effort
over the past 10 years, in an effort to harness their regenerative and immune-modulating …

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential

E Gorman, J Millar, D McAuley… - Expert review of …, 2021 - Taylor & Francis
Introduction: Mesenchymal stromal (stem) cell (MSC) therapies are emerging as a promising
therapeutic intervention in patients with Acute Respiratory Distress Syndrome (ARDS) and …

Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?

GF Curley, CM O'Kane, DF McAuley… - American Journal of …, 2024 - atsjournals.org
There is considerable interest in the potential for cell-based therapies, particularly
mesenchymal stromal cells (MSCs) and their products, as a therapy for acute respiratory …

The inflammatory lung microenvironment; a key mediator in MSC licensing

H Dunbar, DJ Weiss, S Rolandsson Enes, JG Laffey… - Cells, 2021 - mdpi.com
Recent clinical trials of mesenchymal stromal cell (MSC) therapy for various inflammatory
conditions have highlighted the significant benefit to patients who respond to MSC …

Cell therapy for lung disease: current status and future prospects

S Rolandsson Enes, DJ Weiss - Current Stem Cell Reports, 2020 - Springer
Abstract Purpose of Review Mesenchymal stromal cell (MSC)–based therapies provide a
platform for new therapeutic strategies in lung diseases. This review provides an overview of …

Mesenchymal stem cell‐based therapy of inflammatory lung diseases: current understanding and future perspectives

CR Harrell, R Sadikot, J Pascual… - Stem cells …, 2019 - Wiley Online Library
During acute or chronic lung injury, inappropriate immune response and/or aberrant repair
process causes irreversible damage in lung tissue and most usually results in the …

Translating basic research into safe and effective cell-based treatments for respiratory diseases

L Ikonomou, DE Wagner, L Turner… - Annals of the American …, 2019 - atsjournals.org
Respiratory diseases, such as chronic obstructive pulmonary disease and pulmonary
fibrosis, result in severely impaired quality of life and impose significant burdens on …