Although the regulation of arterial blood flow has been a subject of intensive medical
research, the precise circulatory mechanisms involved are still not fully understood. It has …

Although β-blockers have been endorsed by guidelines committees for the treatment of
patients with hypertension, particularly those with significant CVD and high CVD risk, there …

Background Vascular endothelial dysfunction may predict future atherosclerosis. Hence, an
antihypertensive agent that reverses endothelial dysfunction and lowers blood pressure …

A number of structural and functional mechanisms have been identified in the pathogenesis
of hypertensive vascular disease, each of which requires effective therapy to reduce global …

Endothelial dysfunction, which is defined by decreased endothelium-dependent
vasodilatation, is associated with an increased number of cardiovascular events. Nitric oxide …

Endothelium-derived nitric oxide is not only a potent vasodilator but also inhibits platelet
aggregation, smooth muscle cell proliferation, monocyte adhesion and adhesion molecule …

Nebivolol (Bystolic®) is a cardioselective beta 1 (β1)‐adrenergic receptor blocker with
endothelium‐dependent vasodilating properties. The endothelium‐dependent relaxation …

The endothelium is now recognized not only as a physical barrier between blood and
vascular wall, but also as an important and strategically located organ with multiple …

Essential hypertension is associated with impaired endothelium-dependent vasodilation
and is caused mainly by production of oxygen free radicals that can destroy nitric oxide …

Arterial stiffness plays a key role in the pathophysiology of the cardiovascular system. Some
indices of arterial stiffness (pulse wave velocity, augmentation index, characteristics of …