Airway dendritic cells: Co‐ordinators of immunological homeostasis and immunity in the respiratory tract

PA Stumbles, JW Upham, PG Holt - Apmis, 2003 - Wiley Online Library
The large quantities and complex mixtures of antigens encountered daily at airway mucosal
and alveolar surfaces pose a major challenge to maintenance of immunological …

Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation

H Hammad, BN Lambrecht - Journal of allergy and clinical immunology, 2006 - Elsevier
Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host …

The role of dendritic cells in immune regulation and allergic airway inflammation

JW Upham - Respirology, 2003 - Wiley Online Library
Dendritic cells (DC) are potent antigen presenting cells that display an extraordinary
capacity to present antigen to naïve T‐cells and initiate primary immune responses. In the …

Lung dendritic cells and the inflammatory response

MH Grayson - Annals of Allergy, Asthma & Immunology, 2006 - Elsevier
OBJECTIVE: To discuss the role of conventional and plasmacytoid dendritic cells in inducing
and modulating immune responses in the lung. DATA SOURCES: The primary literature and …

Dendritic cells in human lung disease: recent advances

JW Upham, Y Xi - Chest, 2017 - Elsevier
Dendritic cells (DCs) are potent antigen-presenting cells. Because of their particular ability to
initiate and regulate cell mediated and humoral immune responses, there is considerable …

[HTML][HTML] Division of labor between dendritic cell subsets of the lung

CH GeurtsvanKessel, BN Lambrecht - Mucosal immunology, 2008 - Elsevier
Dendritic cells (DCs) are a heterogenous population of antigen-presenting cells, of which
conventional DCs and plasmacytoid DCs are the main subsets. Like DC subsets in the …

Pulmonary dendritic cells in local immunity to inert and pathogenic antigens in the respiratory tract

PG Holt - Proceedings of the American Thoracic Society, 2005 - atsjournals.org
Subsets of dendritic cells form a series of highly developed networks throughout the
respiratory tree, and represent the only professional antigen-presenting cells present within …

Respiratory dendritic cells: mediators of tolerance and immunity

RA Langlois, KL Legge - Immunologic research, 2007 - Springer
The respiratory tract is under constant bombardment from both innocuous and pathogenic
material. The decision of how to respond to these challenges is mediated by a specialized …

Dendritic cells in asthma and COPD: opportunities for drug development

M Kool, BN Lambrecht - Current opinion in immunology, 2007 - Elsevier
The lung contains many subsets of dendritic cells that are distributed in various anatomical
compartments. In homeostatic conditions, a fine-tuned balance exists between plasmacytoid …

Dendritic cell subsets and immune regulation in the lung

HJ de Heer, H Hammad, M Kool, BN Lambrecht - Seminars in immunology, 2005 - Elsevier
The lung is continuously exposed to inhaled particles, microbes and harmless antigens to
which either immunity or tolerance is induced. Dendritic cells are mainly recognized for their …