Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety

VT Angelova, NG Vassilev… - Medicinal Chemistry …, 2016 - Springer
A series of new hybrid molecules with a hydrazone fragment were synthesized and
characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance …

New2-((2-(2,4-dinitrophenyl)hydrazineeylidene) derivatives: design, synthesis, in silico, and in vitro anticancer studies

VP Sajjan, LB Anigol, PM Gurubasavaraj… - Journal of …, 2023 - Taylor & Francis
A series of novel hydrazone compounds have been synthesized by the condensation of
hydrazines and different substituted salicylaldehydes at a molar ratio of 1: 1 in one step …

[HTML][HTML] Oxamic acid thiohydrazides and hydrazones based on them as convenient starting compounds for the synthesis of S-and N-containing heterocyclic products …

MM Krayushkin, VN Yarovenko - Arabian Journal of Chemistry, 2024 - Elsevier
The chemistry of hydrazones is currently undergoing intensive development. For example,
thioacylhydrazones, which are synthesized most often from thiosemicarbazides, have …

Synthesis of Novel Hydrazide–Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II

R Çakmak, E Başaran, K Sahin, M Şentürk… - ACS …, 2024 - ACS Publications
The abnormal levels of the human carbonic anhydrase isoenzymes I and II (hCA I and II)
and cholinesterase enzymes, namely, acetylcholinesterase (AChE) and …

Synthesis, structure–activity relationship studies using density functional theory and in silico molecular docking on substituted benzohydrazide derivatives

PM Gurubasavaraj, VP Sajjan, BM Muñoz-Flores… - Journal of Molecular …, 2024 - Elsevier
The present study demonstrates the utility of benzohydrazide derivatives based on an
approach to identify potential targets for a series of synthesized compounds that show potent …

Hydrazone comprising compounds as promising anti-infective agents: Chemistry and structure-property relationship

PC Sharma, D Sharma, A Sharma, N Saini… - Materials Today …, 2020 - Elsevier
Despite the adverse effects of microbial hazards on public health, major pharmaceutical
firms have left the field of anti-infective development and a dramatic reduction in the number …

[PDF][PDF] Hydrazones as promising lead with diversity in bioactivity-therapeutic potential in present scenario

S Bala, G Uppal, A Kajal, S Kamboj… - Int J Pharm Sci Rev …, 2013 - academia.edu
Hydrazones is an important class of compounds for the development of novel drug moieties.
Hydrazones consists of an azomethine-NHN= CH-proton which is responsible for the …

[HTML][HTML] Synthesis, crystal structure and bioactivity of phenazine-1-carboxylic acylhydrazone derivatives

S Wu, X Liang, F Luo, H Liu, L Shen, X Yang, Y Huang… - Molecules, 2021 - mdpi.com
A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and
2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to …

Synthesis of Novel N-Acylhydrazones and Their CN/NN Bond Conformational Characterization by NMR Spectroscopy

R Munir, N Javid, M Zia-ur-Rehman, M Zaheer… - Molecules, 2021 - mdpi.com
In this article, a synthesis of N'-(benzylidene)-2-(6-methyl-1 H-pyrazolo [3, 4-b] quinolin-1-yl)
acetohydrazides and their structural interpretation by NMR experiments is described in an …

Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells

SM Parameshwaraiah, R Shivakumar… - Chemistry & …, 2024 - Wiley Online Library
The increased expression of VEGFR‐2 in a variety of cancer cells promotes a cascade of
cellular responses that improve cell survival, growth, and proliferation. Heterocycles are …