Inflammatory lung diseases such as bronchial asthma and the adult respiratory distress
syndrome are characterized by a variety of pathophysiologic features, including increased …

Sphingolipids are bioactive lipids involved in the regulation of cell survival, proliferation, and
the inflammatory response. The SphK/S1P/S1PR pathway (S1P pathway) is a driver of many …

The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

The respiratory tract is continually exposed to various insults that are a permanent threat to
the maintenance of lung homeostasis. Repair of the parenchyma structure, particularly of the …

Macrophages act as immune scavengers and are important cell types in the homeostasis of
various tissues. Given the multiple roles of macrophages, these cells can also be found as …

Multiple sclerosis (MS) is a neuroinflammatory disease in which unresolved and
uncontrolled inflammation disrupts normal cellular homeostasis and leads to a pathological …

Chronic pain (CP) is a severe clinical entity with devastating physical and emotional
consequences for patients, which can occur in a myriad of diseases. Often, conventional …

Introduction Cigarette smoke is a profound pro-inflammatory stimulus that contributes to
acute lung injuries and to chronic lung disease including COPD (emphysema and chronic …

Abstract Ceramide 1-phosphate (C1P) is a bioactive sphingolipid metabolite first shown to
regulate cell growth and death. Subsequent studies revealed that C1P was a potent …

Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …