In diabetes, activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) is an
important effector of oxidative-nitrosative injury, which contributes to the development of …

Nicotinamide is being used in experimental and clinical trials examining the prevention of
type-1 diabetes mellitus. However, the precise mechanisms underlying the antidiabetic and …

This study evaluated the role of poly (ADP-ribose) polymerase (PARP) in systemic oxidative
stress and 4-hydoxynonenal adduct accumulation in diabetic peripheral neuropathy. Control …

Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy,
but the mechanisms remain unidentified. Here we provide evidence that poly (ADP-ribose) …

Poly (ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of
diabetes complications, is considered a downstream effector of oxidative-nitrosative stress …

The study has been undertaken to evaluate the effect of streptozotocin (STZ)-induced
diabetes on rat brain poly (ADP-ribose) polymerase (Parp) activity and assess whether and …

Peripheral diabetic neuropathy is a heterogeneous group of disorders, and is known to
affect 50–60% of diabetic patients. Poly (ADP-ribose) polymerase (PARP) activation has …

Poly (ADP-ribose) polymerase (PARP) activation is emerging as a fundamental mechanism
in the pathogenesis of diabetes complications including diabetic neuropathy. This study …

Recent work has demonstrated that hyperglycemia-induced overproduction of superoxide
by the mitochondrial electron-transport chain triggers several pathways of injury [(protein …

Evidence that poly (ADP-ribose) polymerase (PARP) activation plays an important role in
diabetic complications is emerging. This study evaluated the role of PARP in rat and mouse …