Importance of the field: Oxidative stress has been implicated in the pathogenesis of
pulmonary emphysema. Nuclear factor erythroid-2-related factor 2 (Nrf2) a major antioxidant …

Several convergent destructive mechanisms such as oxidative stress, alveolar cell
apoptosis, extracellular matrix proteolysis and chronic inflammation contribute to chronic …

Inflammation, protease/anti‐protease imbalance and oxidative stress play important roles in
the pathogenesis of emphysema. Nrf2 counteracts oxidative tissue damage and …

Although inflammation and protease/antiprotease imbalance have been postulated to be
critical in cigarette smoke–induced (CS-induced) emphysema, oxidative stress has been …

Pulmonary fibrosis is a chronic, progressive, incurable interstitial lung disease with high
mortality after diagnosis and remains a global public health problem. Despite advances and …

Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …

Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …

Pulmonary macrophages are one of the sources of various antioxidant and detoxification
enzymes for which NF-E2–related factor 2 (Nrf2) is a key transcriptional factor. Although Nrf2 …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder in which excessive
deposition of extracellular matrix leads to irreversible scarring of interstitial lung tissue. The …