Abstract Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit
proinflammatory responses of both innate and adaptive immune cells. An association …

Eur J Clin Invest 2012; 42 (1): 95–109 Abstract Background Interleukin‐10 is a pleiotropic
cytokine, whose main function is limitation and ultimately termination of immune responses …

Interleukin 10 receptor (IL10R)− deficient mice develop spontaneous colitis and, similarly,
patients with loss-of-function mutations in IL10R develop severe infant-onset inflammatory …

Summary Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg)
cells are each independently required to maintain immune tolerance. Here we show that IL …

Cytokines maintain intestinal health, but precise intercellular communication networks
remain poorly understood. Macrophages are immune sentinels of the intestinal tissue and …

Crohn's disease and ulcerative colitis are examples of inflammatory bowel disease (IBD),
and are multifaceted chronic autoimmune disorders with unknown etiology; to date, there is …

Abstract Background and Aims Interleukin 6 [IL-6] or its receptor is currently a candidate for
targeted biological therapy of inflammatory bowel disease [IBD]. Thus, a comprehensive …

Immune responses in the intestine are tightly regulated to ensure host protective immunity in
the absence of immune pathology. Interleukin‐23 (IL‐23) has recently been shown to be a …

Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …

Summary Interleukin‐23 (IL‐23) plays an essential role in driving intestinal pathology in
experimental models of both T‐cell‐dependent and innate colitis. Furthermore, genome …