Abstract In Northern America and Europe a great number of people are suffering from birch
pollen allergy and pollen related food allergies. The trigger for these immunological …

Pollen of the European and Asian white birch (Betula pendula and B. platyphylla) causes
hay fever in humans. The allergenic potency of other birch species is largely unknown. To …

Three isoforms of the major birch pollen allergen, Bet v, 1 from Betula verrucosa have been
expressed as recombinant proteins in E. coli and purified. The immunochemical properties …

BACKGROUND: Engineered hypoallergens are currently being investigated for specific
immunotherapy of allergic diseases in preclinical and clinical studies. Naturally occurring …

Specific allergy vaccination is an efficient treatment for allergic disease; however, the
development of safer vaccines would enable a more general use of the treatment …

The term allergy was coined in 1906 by the Austrian scientist and pediatrician Clemens
Freiherr von Pirquet. In 1976, Dietrich Kraft became the head of the Allergy and Immunology …

Bet v 1, the single major allergen from birch pollen, shares IgE epitopes with all major tree
pollen allergens from closely related species such as alder, hazel, hornbeam, beech, and …

Birch pollen allergy is predominantly caused by the major allergen Bet v 1 and can lead to
crossreactions with homologous proteins in food. Two major cross‐reactive food allergens …

The three-dimensional structure of the major birch pollen allergen, the 17,500 M r acidic
protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the …

Background: The major allergen of birch pollen, Bet v 1, is present in structurally slightly
different isoforms. It has been postulated that certain isoforms show a distinct ability to bind …