Background: We analyzed the T cell activation potency and the IgE-binding properties
(allergenicity) of nine isoforms of Bet v 1, the major allergen of birch pollen. Methods: The …

Allergens are antigens that react to specific IgE antibodies. Since the discovery by Charles
Blackley in the 1860s that pollens can cause allergic diseases, the number of allergenic …

Background To date, only limited information on structure, expression levels and IgE binding
of Bet v 1 variants, which are simultaneously expressed in birch pollen, is available …

We have isolated a cDNA clone coding for a birch pollen allergen, Bet v 4. The deduced
amino acid sequence of Bet v 4 contained two typical EF-hand calcium-binding domains …

Background Type I allergy represents a severe health problem in industrialized countries
where up to 20% of the population suffer froin allergic rhinitis, conjunctivitis and allergic …

A preparation of recombinant birch pollen allergen of Betula verrucosa isoform 1a (Bet v 1a)
containing chemically modified (carbamylated) variants has been analyzed by CZE and …

Background: The major birch pollen allergen Bet v 1 (or Bet v 1a) is one of the main causes
of seasonal type I allergies. Various environmental factors such as light, temperature and air …

Background Recombinant Bet v 1a (rBet v 1a) has been used in allergy research for more
than three decades, including clinical application of so-called hypoallergens. Quantitative …

Bet v 1 and homologous proteins represent major cross-reactive allergens for more than
95% of tree pollen-, fruit-, and vegetable-allergic individuals. To study the interaction of Bet v …

Bet v 1, the major birch pollen allergen, represents one of the most prominent allergens. It is
recognized by serum IgE from more than 95% of patients allergic to tree pollen and almost …