Introduction: Functional dyspepsia and non-erosive reflux disease (NERD) are prevalent
gastrointestinal conditions with accumulating evidence regarding an overlap between the …

Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal
disorder, is currently considered as the presence of typical heartburn symptoms in patients …

There is no clear consensus regarding the precise definition of the term refractory GERD.
GERD can be complicated by reflux esophagitis and peptic esophageal strictures, which …

Nonerosive reflux disease (NERD) is the most common phenotype of gastroesophageal
reflux disease. By definition, patients with NERD have typical reflux symptoms caused by the …

Gastroesophageal reflux disease (GERD) is a common disorder in Western countries. For
many years our attention has been focused on patients with erosive esophagitis, but in …

Abstract Background/Aims: The diagnostic criteria for nonerosive reflux disease (NERD) and
functional heartburn (FH) have been changed. We investigated demographic, clinical, and …

Functional heartburn (FH) is defined as a functional esophageal disorder characterized by
symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In …

Although gastroesophageal reflux disease (GERD) is frequently referred to as a continuous
spectrum, it is more useful to consider GERD as 2 discrete entities with several subsets that …

Background When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies
functional esophageal disorders into functional heartburn (FH, with negative reflux‐symptom …

Heartburn is among the most common gastrointestinal symptoms presenting to both
generalist physicians and gastroenterologists. Heartburn that does not respond to traditional …