Background & Aims: Little information is available about the efficacy of proton pump
inhibitors (PPIs) in patients with nonerosive reflux disease (NERD). We aimed to synthesize …

Functional heartburn: An underrecognized cause of PPI-refractory symptoms Page 1 Functional
heartburn: An underrecognized cause of PPI-refractory symptoms CLEVELAND CLINIC …

OBJECTIVES: Endoscopy-negative gastroesophageal reflux disease (GERD) lacks
objective markers of disease severity. Evaluation of therapies for GERD must therefore rely …

Background Up to 40% of patients with non‐erosive reflux disease (NERD) fail to respond to
proton pump inhibitor therapy. Aim To determine useful prognostic factors for response to …

OBJECTIVE: Esophago-gastro-duodenoscopy (EGD) is frequently performed in patients with
heartburn. However, the benefit of an EGD is unclear. The objective is to determine the …

Objectives: We aimed to evaluate the prevalence of irritable bowel syndrome (IBS) in
patients with typical reflux symptoms as distinguished into gastroesophageal reflux disease …

When patients with the typical reflux symptoms of heartburn, regurgitation, or both, undergo
endoscopy, up to 75% will not have endoscopic oesophagitis or evidence of Barrett's …

Background Proton pump inhibitor (PPI)‐refractory heartburn may be due to persistent
gastro‐oesophageal reflux, oesophageal hypersensitivity or functional heartburn (FH). The …

Background The phenotypes of heartburn patients are heterogeneous. Objective The
objective of this study was to investigate the proportion of heartburn phenotypes in a …

Nonerosive reflux disease (NERD) represents the more common phenotypic presentation of
GERD and comprises patients who have typical symptoms without any mucosal breaks at …