OBJECTIVES: The Reflux Disease Questionnaire (RDQ) contains six symptom items for
diagnosing and gauging gastroesophageal reflux disease (GERD) severity. However …

Nonerosive reflux disease (NERD) is the most common type of gastroesophageal reflux
disease (GERD). Its clinical symptoms can recur, and clinical treatment is often ineffective …

Key Clinical Points Gastroesophageal Reflux Disease Patients with heartburn and
symptoms such as dysphagia, odynophagia, weight loss, anorexia, gastrointestinal …

There has been a marked decline over the last several years in drug development for
gastroesophageal reflux disease and specifically for nonerosive reflux disease (NERD) …

Gastroesophageal reflux (GER) is a common gastrointestinal process that can generate
symptoms of heartburn and chest pain. Proton pump inhibitors (PPIs) are the gold standard …

Over the last several decades, the incidences of gastric cancer and peptic ulcer have
declined while the incidences of gastro-oesophageal reflux disease (GORD) and functional …

Non-erosive reflux disease (NERD) is a common condition, characterized by symptoms that
are attributable to reflux of gastric content into the esophagus in the absence of erosive …

Patients with non‐erosive reflux disease (NERD) report symptoms which commonly fail to
improve on conventional antireflux therapies. Oesophageal visceral hyperalgaesia may …

Endoscopic‐negative reflux disease (ENRD) is the most common presentation of gastro‐
oesophageal reflux disease (GERD)—affecting up to 70% of these individuals. In the last …

Background: Recent reports suggest that patients with non‐erosive reflux disease (NERD)
treated with anti‐reflux medications show lower symptom improvement rates than patients …