The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory
phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral …

Stimulator of Interferon Gene (STING) is a critical signaling linker protein that plays a crucial
role in the intrinsic immune response, particularly in the cytoplasmic DNA-mediated immune …

Background: Some neurodegenerative diseases have an element of neuroinflammation that
is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the …

Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA);
however, the mechanism by which DNA damage drives OA is unclear. Previous research …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Background: Aging is a multifactorial process driven by several conditions. Among them,
inflamm-aging is characterized by chronic low-grade inflammation driving aging-related …

Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …

One of the oldest mechanisms of immune defense against pathogens is through detection of
foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the …

The cGAS-STING signaling pathway can trigger innate immune responses by detecting
dsDNA from outside or within the host. In addition, the cGAS-STING signaling pathway has …