[HTML][HTML] Sinularin induces apoptosis through mitochondria dysfunction and inactivation of the pI3K/Akt/mTOR pathway in gastric carcinoma cells

YJ Wu, BS Wong, SH Yea, CI Lu, SH Weng - Marine drugs, 2016 - mdpi.com
Sinularin is an active compound isolated from the cultured soft coral Sinularia flexibilis. In
this study, we investigated the effects of sinularin on two human gastric cancer cell lines …

[HTML][HTML] Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells

TW Chung, SC Lin, JH Su, YK Chen, CC Lin… - … and alternative medicine, 2017 - Springer
Background Sinularin isolated from the cultured soft coral Sinularia flexibilis has been
reported to exert potent cytotoxic effects against particular types of cancer. This study was …

[HTML][HTML] Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells

CA Neoh, RYL Wang, ZH Din, JH Su, YK Chen, FJ Tsai… - Marine drugs, 2012 - mdpi.com
Sinulariolide, an isolated compound from the soft coral Sinularia flexibilis, possesses the
anti-proliferative, anti-migratory and apoptosis-inducing activities against the TSGH bladder …

[HTML][HTML] Sinularin, an anti-cancer agent causing mitochondria-modulated apoptosis and cytoskeleton disruption in human hepatocellular carcinoma

CY Ko, PC Shih, PW Huang, YH Lee, YF Chen… - International journal of …, 2021 - mdpi.com
Liver cancer remains a leading cause of death, despite advances in anti-cancer therapies.
To develop novel drugs, natural products are being considered as a good source for …

[HTML][HTML] Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway

YJ Chen, JH Su, CY Tsao, CT Hung, HH Chao, JJ Lin… - Molecules, 2013 - mdpi.com
Sinulariolide, an active compound isolated from the cultured soft coral Sinularia flexibilis,
has potent anti-microbial and anti-tumorigenesis effects towards melanoma and bladder …

[HTML][HTML] Sinularin selectively kills breast cancer cells showing G2/M arrest, apoptosis, and oxidative DNA damage

HW Huang, JY Tang, F Ou-Yang, HR Wang, PY Guan… - Molecules, 2018 - mdpi.com
The natural compound sinularin, isolated from marine soft corals, is antiproliferative against
several cancers, but its possible selective killing effect has rarely been investigated. This …

[HTML][HTML] Sinularin exerts anti-tumor effects against human renal cancer cells relies on the generation of ROS

Q Ma, XY Meng, KR Wu, JZ Cao, R Yu, ZJ Yan - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Sinularin, a soft corals-derived natural product, exerts anti-tumorigenic activity in various
types of human cancer cells. However, the action of Sinularin and its mechanism in renal …

[HTML][HTML] Proteomic investigation of the sinulariolide-treated melanoma cells A375: Effects on the cell apoptosis through mitochondrial-related pathway and activation of …

HH Li, JH Su, CC Chiu, JJ Lin, ZY Yang, WI Hwang… - Marine drugs, 2013 - mdpi.com
Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis.
In this study, we investigated the effects of sinulariolide on A375 melanoma cell growth and …

Sinularin induces oxidative stress‐mediated G2/M arrest and apoptosis in oral cancer cells

YT Chang, CY Wu, JY Tang, CY Huang… - Environmental …, 2017 - Wiley Online Library
Soft corals‐derived natural product, sinularin, was antiproliferative against some cancers but
its effect and detailed mechanism on oral cancer cells remain unclear. The subject of this …

[HTML][HTML] Sinularin induces oxidative stress-mediated apoptosis and mitochondrial dysfunction, and inhibits angiogenesis in glioblastoma cells

SY Hsu, ZH Wen, PC Shih, HM Kuo, SC Lin, HT Liu… - Antioxidants, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is a cancer of largely unknown cause that leads to a 5-year
survival rate of approximately 7% in the United States. Current treatment strategies are not …