[HTML][HTML] Sinularin induces apoptosis through mitochondria dysfunction and inactivation of the pI3K/Akt/mTOR pathway in gastric carcinoma cells
YJ Wu, BS Wong, SH Yea, CI Lu, SH Weng - Marine drugs, 2016 - mdpi.com
Sinularin is an active compound isolated from the cultured soft coral Sinularia flexibilis. In
this study, we investigated the effects of sinularin on two human gastric cancer cell lines …
this study, we investigated the effects of sinularin on two human gastric cancer cell lines …
[HTML][HTML] Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells
Background Sinularin isolated from the cultured soft coral Sinularia flexibilis has been
reported to exert potent cytotoxic effects against particular types of cancer. This study was …
reported to exert potent cytotoxic effects against particular types of cancer. This study was …
[HTML][HTML] Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells
CA Neoh, RYL Wang, ZH Din, JH Su, YK Chen, FJ Tsai… - Marine drugs, 2012 - mdpi.com
Sinulariolide, an isolated compound from the soft coral Sinularia flexibilis, possesses the
anti-proliferative, anti-migratory and apoptosis-inducing activities against the TSGH bladder …
anti-proliferative, anti-migratory and apoptosis-inducing activities against the TSGH bladder …
[HTML][HTML] Sinularin, an anti-cancer agent causing mitochondria-modulated apoptosis and cytoskeleton disruption in human hepatocellular carcinoma
CY Ko, PC Shih, PW Huang, YH Lee, YF Chen… - International journal of …, 2021 - mdpi.com
Liver cancer remains a leading cause of death, despite advances in anti-cancer therapies.
To develop novel drugs, natural products are being considered as a good source for …
To develop novel drugs, natural products are being considered as a good source for …
[HTML][HTML] Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway
YJ Chen, JH Su, CY Tsao, CT Hung, HH Chao, JJ Lin… - Molecules, 2013 - mdpi.com
Sinulariolide, an active compound isolated from the cultured soft coral Sinularia flexibilis,
has potent anti-microbial and anti-tumorigenesis effects towards melanoma and bladder …
has potent anti-microbial and anti-tumorigenesis effects towards melanoma and bladder …
[HTML][HTML] Sinularin selectively kills breast cancer cells showing G2/M arrest, apoptosis, and oxidative DNA damage
HW Huang, JY Tang, F Ou-Yang, HR Wang, PY Guan… - Molecules, 2018 - mdpi.com
The natural compound sinularin, isolated from marine soft corals, is antiproliferative against
several cancers, but its possible selective killing effect has rarely been investigated. This …
several cancers, but its possible selective killing effect has rarely been investigated. This …
[HTML][HTML] Sinularin exerts anti-tumor effects against human renal cancer cells relies on the generation of ROS
Q Ma, XY Meng, KR Wu, JZ Cao, R Yu, ZJ Yan - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Sinularin, a soft corals-derived natural product, exerts anti-tumorigenic activity in various
types of human cancer cells. However, the action of Sinularin and its mechanism in renal …
types of human cancer cells. However, the action of Sinularin and its mechanism in renal …
[HTML][HTML] Proteomic investigation of the sinulariolide-treated melanoma cells A375: Effects on the cell apoptosis through mitochondrial-related pathway and activation of …
Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis.
In this study, we investigated the effects of sinulariolide on A375 melanoma cell growth and …
In this study, we investigated the effects of sinulariolide on A375 melanoma cell growth and …
Sinularin induces oxidative stress‐mediated G2/M arrest and apoptosis in oral cancer cells
YT Chang, CY Wu, JY Tang, CY Huang… - Environmental …, 2017 - Wiley Online Library
Soft corals‐derived natural product, sinularin, was antiproliferative against some cancers but
its effect and detailed mechanism on oral cancer cells remain unclear. The subject of this …
its effect and detailed mechanism on oral cancer cells remain unclear. The subject of this …
[HTML][HTML] Sinularin induces oxidative stress-mediated apoptosis and mitochondrial dysfunction, and inhibits angiogenesis in glioblastoma cells
Glioblastoma multiforme (GBM) is a cancer of largely unknown cause that leads to a 5-year
survival rate of approximately 7% in the United States. Current treatment strategies are not …
survival rate of approximately 7% in the United States. Current treatment strategies are not …