Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae

CV Nogueira, X Zhang, N Giovannone… - The Journal of …, 2015 - journals.aai.org
Understanding the cellular populations and mechanisms responsible for overcoming
immune compartmentalization is valuable for designing vaccination strategies targeting …

Prior Genital Tract Infection with a Murine or Human Biovar of Chlamydia trachomatis Protects Mice against Heterotypic Challenge Infection

KH Ramsey, TW Cotter, RD Salyer… - Infection and …, 1999 - Am Soc Microbiol
We sought to assess the degree of cross-protective immunity in a mouse model of
chlamydial genital tract infection. Following resolution of genital infection with the mouse …

Vaccination with the Chlamydia trachomatis Major Outer Membrane Protein Can Elicit an Immune Response as Protective as That Resulting from Inoculation with …

S Pal, EM Peterson, LM de la Maza - Infection and immunity, 2005 - Am Soc Microbiol
ABSTRACT BALB/c mice were vaccinated by the intramuscular (im) and subcutaneous (sc)
routes with a native preparation of the Chlamydia trachomatis mouse pneumonitis (MoPn) …

Neutrophils are central to antibody-mediated protection against genital Chlamydia

EK Naglak, SG Morrison, RP Morrison - Infection and immunity, 2017 - Am Soc Microbiol
Determining the effector populations involved in humoral protection against genital
chlamydia infection is crucial to development of an effective chlamydial vaccine. Antibody …

Immunity to murine chlamydial genital infection

RP Morrison, HD Caldwell - Infection and immunity, 2002 - Am Soc Microbiol
Chlamydia trachomatis sexually transmitted infections cause considerable morbidity and
socioeconomic burden worldwide, despite significant advances in our understanding of the …

Considerations for the rational design of a Chlamydia vaccine

S Liang, D Bulir, C Kaushic… - Human vaccines & …, 2017 - Taylor & Francis
Chlamydia trachomatis is the leading cause of preventable blindness and the most common
bacterial sexually transmitted infection. Remarkable progress in vaccine research over the …

Immunopathogenesis of genital Chlamydia infection: insights from mouse models

J Dockterman, J Coers - Pathogens and Disease, 2021 - academic.oup.com
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases
throughout the globe, affecting the eye, lung, coronary arteries and female genital tract …

Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea …

DW Andrew, LM Hafner, KW Beagley… - Journal of reproductive …, 2011 - Elsevier
Chlamydia trachomatis is a major cause of sexually transmitted diseases worldwide. There
is currently no vaccine to protect against chlamydial infection of the female reproductive …

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

C Lu, J Wang, G Zhong - Infection and immunity, 2023 - Am Soc Microbiol
To search for subunit vaccine candidates, immunogenic chlamydial antigens identified in
humans were evaluated for protection against both infection and pathology in a mouse …

The mouse model of Chlamydia genital tract infection: a review of infection, disease, immunity and vaccine development

CP O'Meara, DW Andrew… - Current molecular …, 2014 - ingentaconnect.com
Chlamydia trachomatis is the most common sexually transmitted bacterial infection
worldwide. The impact of this pathogen on human reproduction has intensified research …