Chlamydia trachomatis is the most commonly reported bacterial sexually transmitted
infection in the United States. Modeling infection in animals can be challenging, as mice …

Protective sequences of Chlamydia muridarum were identified as potential vaccine
candidates by screening a genomic DNA expression library and assessing the immune …

Murine vaginal infection with the obligate intracellular bacterium Chlamydia muridarum is
commonly used as a model for ascending Chlamydia infections of the human female genital …

Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection
globally. These infections translate to a significant public health burden, particularly …

Whether there is a pathogenic or protective outcome to chlamydial infection may be defined
by the host response. We infected C57BL/6 (C57) and C3H/HeN (C3H) mice with the human …

The induction of local T helper type 1 (Th1)-mediated cellular immunity is crucial for
resistance of mice to genital infection by the obligate intracellular bacterium Chlamydia …

Here we report on the safety, immunogenicity, and vaccine efficacy of the naturally occurring
plasmid-free attenuated Chlamydia trachomatis L2-25667R (L2R) strain in a murine …

The failure of the inactivated Chlamydia-based vaccine trials in the 1960s has led
researchers studying Chlamydia to take cautious and rational approaches to develop safe …

The search for a safe and efficacious human chlamydial vaccine has been ongoing for more
than 5 decades. Unfortunately, the dream has yet to be realized. However, much progress …

Chlamydia has been detected in the gastrointestinal tracts of humans and animals. We now
report that gastrointestinal Chlamydia muridarum is able to induce robust transmucosal …