Professor Marcello Costa (AO, FAA) was a pioneer and leader in the field of autonomic
neuroscience, specifically the intrinsic neural circuits of the enteric nervous system. From the …

Neurogastroenterology encompasses intrinsic and extrinsic neural processes that regulate
gut functions, sensation and related behaviors such as ingestion. In 2011, key advances …

Background Serving as a reservoir, the gastric fundus can expand significantly, with an
initial receptive and a following adaptive relaxation, controlled by extrinsic and intrinsic …

The esophagus consists of two anatomically and physiologically distinct regions, namely a
proximal striated muscle portion (cervical esophagus) and a distal smooth muscle portion …

We recently found that an orally directed stretch of the esophagus activates a neurally
mediated relaxation of the lower esophageal sphincter (LES). Goals of our study were to …

The enteric nervous system regulates autonomously from the central nervous system all the
reflex pathways that control blood flow, motility, water and electrolyte transport and acid …

The relationship between stress and gastrointestinal function is poorly understood and of
major clinical importance as a potential contributor to irritable bowel syndrome, functional …

Abstract Background/Aims: Esophageal motor abnormalities are frequently found in patients
with gastroesophageal reflux disease. The effect of bile in esophageal dysmotility is …

Since the development of knockout animals, the mouse has become an important model to
study gastrointestinal motility. However, little information is available on the electrical and …

Background Esophageal hypercontractility can manifest with and without esophagogastric
junction (EGJ) outflow obstruction. We investigated clinical presentations and motility …