Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …

Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse
prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human …

Abstract Background Systemic sclerosis (SSc) is a multi-organ autoimmune disease
characterized by skin fibrosis. Internal organ involvement is heterogeneous. It is unknown …

Organ fibrosis represents a vital health threat that substantially contributes to yearly mortality
rates. While a considerable amount of research has been conducted on fibrosis, these …

Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …

Fibroproliferative diseases of organs are poorly understood and generally lack effective anti-
fibrotic treatments. Our goal was to identify the key regulatory factors in pathologic fibrosis …

Fibrosis, a progressive accumulation of extracellular matrix components, encompasses a
wide spectrum of distinct organs, and accounts for an increasing burden of morbidity and …

Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an
uncontrolled wound healing response to injury in which tissue is replaced by deposition of …

Virtually all diseases affect multiple organs. However, our knowledge of the body-wide
effects remains limited. Here, we report the body-wide transcriptome landscape across 13 …

Single cell genomics enables characterization of disease specific cell states, while
improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics …