The correspondence of cell state changes in diseased organs to peripheral protein
signatures is currently unknown. Here, we generated and integrated single‐cell …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

Background Fibrosis in most organs has proven to be an critical factor related to high risk of
morbidity and mortality, but an adequate assessment of fibrosis severity is still challenging …

Myeloid cells localize to peripheral tissues in a wide range of pathologic contexts. However,
appreciation of distinct myeloid subtypes has been limited by the signal averaging inherent …

Pulmonary fibrosis (PF) is a heterogeneous disease with a poor prognosis. Therefore,
identifying additional therapeutic modalities is required to improve outcome. However, the …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …

Cardiometabolic diseases are an increasing global health burden. While socioeconomic,
environmental, behavioural, and genetic risk factors have been identified, a better …

Tissue-based functional genomics resources including molecular quantitative trait loci
datasets lack diversity in ancestry and tissue types and thus are inadequate for …

Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

Precision health relies on the ability to assess disease risk at an individual level, detect early
preclinical conditions and initiate preventive strategies. Recent technological advances in …