Fibrosis, the excessive accumulation of extracellular matrix, is a major global healthcare
burden. Despite major advances in our understanding of the mechanisms regulating …

Exchanging and understanding scientific data and their context represents a significant
barrier to advancing research, especially with respect to information siloing. Maintaining …

In the skin, tissue injury results in fibrosis in the form of scars composed of dense
extracellular matrix deposited by fibroblasts. The therapeutic goal of regenerative wound …

Background Inter-tissue molecular interactions are critical to the function and behavior of
biological systems in multicellular organisms, but systematic studies of interactions between …

Multiomic profiling can reveal population heterogeneity for both health and disease states.
Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic …

The intestinal microbiota is a complex community of bacteria, archaea, viruses, protists and
fungi,. Although the composition of bacterial constituents has been linked to immune …

Linking putatively pathogenic variants to the tissues they affect is necessary for determining
the correct diagnostic workup and therapeutic regime in undiagnosed patients. Here, we …

Important studies in 2021 demonstrated sophisticated developments in the study of liver
fibrosis through omics. Cell-specific mapping, single-cell sequencing and deep-learning …

Personalized medicine is rapidly emerging as the future direction in the post–genome
sequencing era. Early applications have concentrated on variant‐based assessment of …

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive
fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better …