Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to
proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle soon after birth in
mammals. Although the extent to which adult cardiac myocytes are capable of cell cycle …

The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …

In recent years, there has been a dramatic increase in research aimed at regenerating the
mammalian heart by promoting endogenous cardiomyocyte proliferation. Despite many …

The human heart does not regenerate. Instead, following injury, human hearts scar. The loss
of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans …

The adult mammalian heart is incapable of clinically relevant regeneration. The regenerative
deficit in adult mammalian heart contrasts with the fetal and neonatal heart, which …

Cardiovascular disease remains the leading cause of mortality worldwide. Cardiomyocytes
are irreversibly lost due to cardiac ischemia secondary to disease. This leads to increased …

Cardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of
cardiac function and ultimately to congestive heart failure. Despite significant advances …

Cardiomyocytes proliferate profusely during early development and for a brief period after
birth in mammals. Within a month after birth, this proliferative capability is dramatically …