Introduction HIV/AIDS remains a major health concern worldwide, with sub-Saharan Africa
(SSA) carrying the largest burden. HIV is characterised by extremely high genetic diversity …

Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have
become part of the preferred antiretroviral therapy (ART) first-line regimen in most low-to …

The growing emergence of non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV drug
resistance in sub-Saharan Africa (SSA) led to the World Health Organization (WHO) …

Background: Integrase strand transfer inhibitors (INSTIs) are the latest addition to the array
of antiretroviral compounds used to treat an infection with Human Immunodeficiency Virus …

HIV-1 integrase enzyme is responsible for the integration of viral DNA into the host genomic
DNA. Integrase strand transfer inhibitors (INSTIs) are highly potent antiretroviral agents that …

Background Although biochemical analysis of HIV-1 integrase enzyme suggested the use of
integrase inhibitors (INIs) against HIV-1C, different viral subtypes may favor different …

Objective: Dolutegravir (DTG) is now a preferred component of first-line antiretroviral therapy
(ART). However, prevalence data on natural resistance to integrase inhibitors [integrase …

Integrase strand-transfer inhibitors (INSTIs) are now included in preferred first-line
antiretroviral therapy (ART) for HIV-infected adults. Studies of Western clade-B HIV-1 show …

Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …

HIV‐1 genetic diversity and drug resistance mutations remain public health challenges
especially in regions where treatment is limited. The aim of this study was to characterize the …